HER2/ErbB2
€350.00
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SKU: P2020-165 trenzyme
Description
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, is a receptor tyrosine kinase that plays a crucial role in regulating cell growth, proliferation and survival. Additionally, HER2 signaling promotes cell migration, adhesion and invasion, essential for normal tissue development and wound healing. However, dysregulation of HER2 signaling, due to gene amplification or overexpression, leads to uncontrolled cell growth, tumor formation, and metastasis. Therefore, HER2 has emerged as an important therapeutic target in various cancer types, especially in breast cancer, where HER2-targeted therapies have significantly improved treatment outcomes.
Overview
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Product Name: HER2/ErbB2
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Catalog No.: His-Tag: P2020-165; Fc/His-Tag: P2020-166
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RefSeq Links: HGNC:3430; NX_P04626; NP_004439.2; NM_004448.3; PDBe 7mn6; UniProt: P04626
- Synonyms: ERBB2, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, NEU, NGL, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, HER2, HER-2, p185erbB2, CD340
Sequence Information
- Species: Homo sapiens
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Tags:
P2020-165: His-tag, C-terminal;
P2020-166: Fc/His-tag, C-terminal -
Sequence without tags (AA 22-652):
MSTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEV
QGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLREL
QLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCK
GSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNH
SGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQ
EVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPES
FDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGA
YSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRP
EDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHC
LPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEE
GACQPCPINCTHSCVDLDDKGCPAEQRASPLT
Product Information
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Expression Host: HEK293
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Formulation: PBS; pH 7.4
- Format: Liquid, stored and shipped at -80° C
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Purity: > 80 % as determined by SDS-PAGE
- Application: WB, Kinase assay
Background Information
The human epidermal growth factor receptor 2 (HER2), which is also referred to as ErbB2 as it is encoded by the ERBB2 gene (erythroblastic oncogene B), is a receptor tyrosine kinase that belongs to the epidermal growth factor receptor (EGFR) family. The EGFR family consists of four members, including ErbB1 (HER1), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4). All members share a similar structure, containing an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. Intriguingly, HER2 is the only one, which does not directly bind any ligand. Instead, hetero-dimerization with any of the other three receptors upon ligand engagement results in auto-phosphorylation on the intracellular tyrosine kinase domain, thereby initiating a myriad of downstream signaling pathways. In HER2 overexpressing cells, HER2 forms also homodimers, but as an orphan receptor in a ligand-independent manner. HER2 signaling pathways are intricate networks of molecular interactions that regulate cellular processes, including cell growth, proliferation, differentiation, and survival. Thus, HER2 is essentially involved in maintaining tissue homeostasis. Moreover, HER2 signaling promotes cytoskeletal rearrangements, cell migration and the expression of metalloproteinases (MPPs) involved in extracellular matrix remodeling and invasion. Aberrant HER2 signaling, due to gene amplification or overexpression, results in uncontrolled cell growth and metastasis, encouraging the development and progression of cancer. Dysregulation of HER2 is associated with various cancer types, most prominently breast cancer. Therefore, HER2-targeted therapies, including monoclonal antibodies and small molecule inhibitors, are being developed. Therapeutics, such as trastuzumab (Herceptin), pertuzumab (Perjeta), and ado-trastuzumab emtansine (Kadcyla), have revolutionized the treatment of HER2-positive breast cancer cells, significantly improving patient survival.
Additional information HER2/ErbB2 His-tag
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SDS-PAGE/Coll. Coomassie |
Histogram of marked lane in gel picture |
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Additional information HER2/ErbB2 Fc/His-tag
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SDS-PAGE/Coll. Coomassie |
Histogram of marked lane in gel picture |
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