Human Serum Albumin, His-Tag
€90.00
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SKU: P2020-168 trenzyme
Description
Human serum albumin (HSA) is the most abundant plasma protein in the human blood and plays pivotal roles in various physiological processes, including maintenance of osmotic pressure, transporting molecules, buffering pH, and modulating colloidal pressure. Clinically, HSA is widely used to treat several diseases, such as hypovolemia, shock, burns, trauma, surgical blood loss, acute and chronic liver failure, and hypoalbuminemia. Moreover, HSA serves as valuable diagnostic marker for assessing liver function, nutritional status and inflammatory conditions. Due to its versatile functions, HSA-based therapies may provide improved pharmacokinetics, extended half-life in the circulation, enhanced efficacy and reduced toxicity.
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Overview
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Product Name: Human Serum Albumin, His-Tag
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Catalog No.: P2020-168
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RefSeq Links: HGNC:399; NX_P02768; NP_000468.1; NM_000477.6; PDBe 6hsc; UniProt: P02768
- Synonyms: ALB, Albumin, Serum albumin, HSA
Sequence Information
- Species: Homo sapiens
- Tags: His-tag, C-terminal
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Sequence without tags (AA 19-609):
MRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTC
VADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLP
RLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAAD
KAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSK
LVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEV
ENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTY
ETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTK
KVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRV
TKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELV
KHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL
Product Information
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Expression Host: HEK293
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Formulation: PBS; pH 7.4
- Format: Liquid, stored and shipped at -80° C
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Purity: > 90 % as determined by SDS-PAGE
- Application: ELISA, WB
Background Information
Human serum albumin (HSA) is a ubiquitous protein of the human blood plasma, constituting approximately half of the total protein content. Due to its exceptional ligand-binding capacity, HSA serves as multifunctional carrier protein, transporting various endogenous and exogenous ligands, including fatty acids, bilirubin, hormones, metal ions, and drugs. Its ability to bind these ligands with high affinity and specificity facilitates their distribution, metabolism, and elimination within the body. Additionally, HSA acts as scavenger of reactive oxygen species (ROS), thereby preventing oxidative damage to cells and tissues. Furthermore, HSA essentially contributes to the regulation of oncotic pressure to ensure fluid balance between the intravascular and interstitial compartments and to prevent edema. Its unique properties prove HSA useful in several clinical applications. HSA is commonly used as a plasma expander to restore blood volume in patients with hypovolemia or shock. In addition, HSA-based solutions are employed in the formulation of pharmaceutical drugs to enhance their solubility, stability, and pharmacokinetic profiles. Moreover, HSA represents a valuable diagnostic marker used to assess liver function, nutritional status, and inflammatory conditions.
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SDS-PAGE/Coll. Coomassie |
Histogram of marked lane in gel picture |
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